Beyond High-Purity Purification
However, structural analysis after synthesis or purification by preparative LC is time-consuming and recovering high-purity samples is very difficult. Therefore, as a solution to this problem, Shimadzu offers the Crude2Pure system, which recovers target compounds in high-purity powder based on a revolutionary purification method that involves using two purification systems.
The Ultrahigh-Speed Preparative Purification System, Prominence UFPLC system, the newest addition to Shimadzu’s family of purification systems, inherits the same purification method as the Crude2Pure, but handles all steps, from fractionation to purification, within a single system, so that target compounds can be recovered in high-purity solution.
One System Handles It All
A New Solution for Preparative Purification in Operations
Ranging from Analysis to Semi-Preparative Purification
*1 Total time depends on the combination of Prominence UFPLC and Evaporation system (provided preparative time is 30 min).
Note: Contact your Shimadzu sales representatives for details about configurations, specifications, etc.
Building systems appropriate to your purposes
This is the most basic Prominence UFPLC system.
Automated Preparative Purification is available when there is only one target compound.
This is a fully automated system to purify several compounds, including the main target compound, residual substance and impurities (five kinds at max.), from a preparative sample.
Recover High-Purity Liquid by Eliminating Solvent Components
Mobile phases used for HPLC separation for pharmaceutical components sometimes include compounds like trifluoroacetate that form counter ions. If such components are included in preparative fractions, they can cause problems during drying or testing after purification.
However, the Prominence UFPLC system is able to easily eliminate such components that may be contained in fractionated liquids. Depending on the elimination method selected, target compounds can also be recovered in freebase form, in addition to eliminating components from the mobile phase.
Structural analysis without pretreatment
Easy-to-Operate Dedicated Software
Variety of Fractionation Modes
Automatic Fractionation Mode
Manual Fractionation Mode
When concentrating a sample by reinjecting it multiple times, the function remembers the timing of the first fraction, so that the fraction is automatically performed at the specified time for each injection thereafter.
Time-Specified Fractionation Mode