Trap-Free 2D LC/MS system for Quadrupole LCMS
Enhancing the Efficiency of Impurity Analysis
Question:
When impurities are detected by UV under non-volatile mobile phase conditions, does one need to adapt the method to use volatile mobile phase additives for LCMS confirmation?
Answer:
With the use of a Trap-free 2D LCMS system, no additional method development is required because mobile phases can be changed online.
- Online switching between a non-volatile mobile phase and a volatile mobile phase
- Convenient support tool coordinated within LabSolutions
- Only the impurities of interest are introduced to the MS system, so there are no concerns about peak misalignment.
Creating a Time Program and Batch Schedule using the Support Tool
The optimal valve sequence can be constructed by entering the retention times for impurity peaks observed in the first-dimension UV chromatogram, and then a batch schedule can be created to acquire data on multiple impurities and their respective blanks.
Using the Data Browser Makes Identification of Impurities Easy
Remarks and Precautions
- The Trap-Free 2D LCMS System is a application system and is configured with LC units, Quadrupole mass spectrometer, and start kit
News / Events
-
GCMS-QP2050 Gas Chromatograph Mass Spectrometer Video has released
The business environments and needs involved in analysis work change on a continual basis. The next-generation GCMS-QP2050 gas chromatograph mass spectrometer, with its accumulation of impressive Shimadzu technology, will lead the way forward. New value is provided by hardware boasting astounding reliability and stability, and easy-to-operate software equipped with superior automated technology.
-
OAD-TOF system Interview with Dr.Hiroshi Tsugawa
The OAD-TOF system is a Q-TOF LCMS that realizes OAD (Oxygen Attachment Dissociation), Shimadzu's proprietary fragmentation technology. It allows the analysis of the position of carbon-carbon double bonds in lipids and other organic compounds. Combined with the LCMS -9050, which boasts world-class high mass accuracy and fast polarity switching, it enables the creation of innovative applications.
-
Metabolic Pathway Analysis Solutions
Metabolic pathways are the chain of chemical and enzymatic reactions that occur within a cell in living organisms to support their life.
-
AOAC INTERNATIONAL Posters are now available.
-
Shimadzu has released the OAD-TOF system
The OAD-TOF system is a Q-TOF LCMS that realizes OAD (Oxygen Attachment Dissociation), Shimadzu's proprietary fragmentation technology. It allows the analysis of the position of carbon-carbon double bonds in lipids and other organic compounds. Combined with the LCMS-9050, which boasts world-class high mass accuracy and fast polarity switching, it enables the creation of innovative applications.
-
Shimadzu has released the LC/MS/MS Method Package for Sugars and Sugar Nucle
The LC/MS/MS Method Package for Sugars and Sugar Nucleotides includes LC/MS/MS analytical methods with analytical conditions and MS parameter settings optimized for analyzing 25 different sugars, amino sugars, sugar acids and sugar alcohols, 9 different sugar nucleotides, related metabolites, and internal standards.