Analysis of Toxicological Substances in Whole Blood Using Smart Forensic Database (1)

By providing mass separation in two stages, GC-MS/MS is capable of separating out interferences in biological samples and toxicological substances. Therefore, it is simple to determine whether toxicological substances are present, significantly reducing the time required for data analysis. In order to analyze toxicological substances in MRM mode, however, MRM transitions and collision energies (CE) must be optimized, which is very labor intensive.

Smart Forensic Database is an MRM database containing retention indices, MRM transitions, collision energies, and quantitation/confirmation ion ratios for 201 toxicological substances often involved in poisonings. The retention times for the registered toxicological substances are accurately estimated simultaneously from lowboiling point components to high-boiling point components, using measurement data from a standard n-alkane mixture via the GCMSsolution AART function. Smart MRM, which is provided with the GCMS-TQ8040, can then create MRM analysis methods automatically using the database.

This article introduces an example of applying Smart Forensic Database to the analysis of toxicological substances in a whole-blood sample.

Content Type:
Application
Document Number:
LAAN-J-MS-E100
Product Type:
Gas Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
whole-blood sample, Clinical research, Forensics, Forensics, Toxicology, Drug test, GCMS-TQ8040, Smart Forensic Database
Language:
English
File Name:
jpo214091.pdf
File Size:
171kb

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