Determination of 1,4-Dioxane in Shampoo Using the OPTIC-4 Multimode Inlet

Difficult matrix introduction (DMI), one of the injection modes provided by the OPTIC-4 multimode inlet, is effective at simplifying the pretreatment process. In this method, the micro vial into which the sample has been placed is put into a liner. The liner is then heated by the inlet so that the target components are introduced into the column. By adjusting the inlet temperature, it is possible to leave the nonvolatile components in the micro vial, enabling GC/MS measurements with simple pretreatment. A method for easily quantifying the amount of 1,4-dioxane in shampoo using DMI was investigated. 1,4-dioxane can be produced in extremely small quantities as a byproduct of the process of manufacturing surfactants, the main component in shampoos and detergent for tableware. It is suspected of causing cancer in humans. The headspace method is often used for this substance. In this case, however, a simple method of quantitative determination utilizing DMI was investigated. In addition, the possibility of consecutive automatic analysis with the AOC-6000, in anticipation of cases in which there are a number of samples, was also investigated.