Automated SPME for the Analysis of Environmental Contaminants in Milk by GC-MS/MS

Organophosphorus (OP) pesticides are a class of insecticides known for their acute toxicity towards a large variety of insects, and a relatively lower persistence in the environment compared to organochlorine pesticides. Gas chromatography mass spectrometry (GC/MS) instrumentation is a powerful tool for the separation and identification of volatile and semi-volatile compounds, including many OP pesticides. Gas chromatography coupled to a triple quadrupole mass spectrometer (GC-MS/MS) allows for even greater separation, as the mass spectrometer is operated in the Multiple Reaction Monitoring (MRM) mode with two stages of mass analysis. This mode of detection virtually eliminates background interference, making GC-MS/MS a powerful technique with improved sensitivity, selectivity, and specificity. Solid Phase Micro-Extraction (SPME) has produced promising results when used as a sample preparation technique for complex matrices. The SPME technique has several desirable advantages; most importantly it does not require the use of harmful organic solvents, and it is easily automated.This poster describes development of a fully automated SPME extraction method combined with GC-MS/MS analysis for detection and quantitation of OP pesticides in a complex milk matrix.

Content Type:
Paper
Document Number:
PO-CON1607E
Product Type:
Mass Spectrometry, Gas Chromatograph-Mass Spectrometry
Keywords:
Milk Solid Phase Micro-Extraction (SPME) Organophosphorus (OP) pesticide organochlorine pesticide, Environment, Food safety (Residues, Contaminants), Agriculture, GCMS-TQ8040
Language:
English
File Name:
sio216019.pdf
File Size:
884kb

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