New Data Processing Method for Photodiode Array Detector

A new data processing method for a photo diode array (PDA) detector, Intelligent Dynamic Range Extension Calculator (i-DReC) enables the automatic calculation of peak area and height, utilizing spectrum similarity in the high concentration range where UV signal is saturated. When the integrated chromatographic peak area exceeds a user-defined threshold value, i-DReC automatically shifts the chromatographic profile to a wavelength with less UV absorption to prevent signal saturation. The absorption ratio between the original target wavelength and the wavelength used by the i-DReC function is applied as a correction factor to the peak area of the acquired chromatogram, thereby calculating the peak area and height at the original target wavelength. The i-DReC dramatically extends the linear dynamic range of calibration curves, enabling reliable quantitation of high concentration samples without need for sample dilution and reinjection, which would otherwise be required.

Content Type:
Application
Document Number:
C190-E167
Product Type:
Liquid Chromatography
Keywords:
PDA data processing, dynamic range extension, Nexera X2, UHPLC, Pharmaceutical, Life Science, DMPK, ADME, Safety testing, LC-30AD
Language:
English
File Name:
jpl213020.pdf
File Size:
569kb

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