Improved Sample Pretreatment Using Offline Supercritical Fluid Extraction

Separation analysis using HPLC, SFC or GC requires a pretreatment step to efficiently extract a target constituent from the sample in various forms (e.g., solid). Constituents are usually extracted from solid samples using dissolution or solid-liquid extraction methods. Dissolution methods can only be used when the sample is soluble in a given solvent, and they are difficult to optimize depending on the analytical conditions. Solid-liquid extraction methods (e.g., Soxhlet extraction) are not suited to the pretreatment of multiple samples as they require considerable time for extraction and non-extraction (e.g., cleaning, preparation) operations. However, extraction methods involving supercritical fluids can utilize the characteristics of supercritical fluids (e.g., high solubility, permeability) to achieve the elution of a target constituent from a solid sample with high efficiency and also allow automation during the extraction process. This article describes the utilization of the Nexera UC SFE pretreatment system, which increases the efficiency of sample pretreatment for analysis.

Content Type:
Application
Document Number:
C190-E199
Product Type:
Liquid Chromatography
Keywords:
supercritical fluid extraction, SFE, offline SFE, Food and Beverages, Pharmaceutical, Life Science, Agriculture, Nexera UC SFE Pretreatment System
Language:
English
File Name:
jpl216019.pdf
File Size:
811kb

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