Analysis of Toxic Elements in Supplements as per USP 2232 Using the ICPMS-2030

The United States Pharmacopeia (USP) 2232 designates permitted daily exposure (PDE) levels for four elements for which toxicity is a concern in dietary supplements. PDE values need to be converted to concentrations when evaluating metallic impurities in formulations or their structural components. Compliance with these regulations is also obligatory for supplements imported to the U.S. from other nations. Here, we introduce a quantitative analysis performed on arsenic, cadmium, mercury, and lead in supplements using the Shimadzu ICPMS-2030 ICP mass spectrometer.