A Highly Sensitivity Method for Quantitative Determination of Ten Phenols in Surface Water on LC/MS/MS with APCI Interface
There are a variety of phenolic compounds such as alkylphenols (AP), chlorophenols (CP), nitrophenols (NP), bisphenol A (BPA) and triclosan, etc. Phenols are widely used as chemical precursors in industries and for other purposes in agriculture, medical and domestic processes. Many phenolic compounds are toxic and carcinogenic to human and they are classified as the priority pollutants in surface and drinking waters. The US Environmental Protection Agency (EPA) and the European Community (EC) have set a legal tolerance level of 0.5 μg/L for total phenols and 0.1 μg/L for individual phenolic compound in drinking water. Japan’s MHLW (Ministry of Health,Labor and Welfare) has designated six phenols as the index of water quality standard requirements. A LCMS-8050 triple quadrupole system with APCI interface was coupled to Nexera UHPLC system was employed in the detection and quantitation of ten phenols in surface waters. A pentafluorophenyl (PFP) column from Phenomenex was used with an optimized gradient elution program (8 minutes) for ten phenols. Two MRM transitions were selected for each compound, with one as quantifying ion and the other for confirmation. Good linearity of R2 > 0.995 was obtained for the calibration range from 0.05 μg/L to 10 μg/L (except for 2,4-dimethylphenol) with 10μL injection volume. The limits of detection (LOD) of the method achieved are better than 0.1 μg/L for each individual compound except phenol and 2,4-dimethylphenol, which LODs are at 1.0 μg/L.
- Content Type:
- Application
- Document Number:
- AD-0125
- Product Type:
- Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
- Keywords:
- Water, Surface Water, Phenols, chlorophenols, nitrophenols, Environment, Discharge Water, Groundwater, Environment Water, LCMS-8050
- Language:
- English
- File Name:
- apo117021.pdf
- File Size:
- 348kb