Development of on-line SFE-SFC system and its application for food contaminant analysis

Sample pretreatment is always one of the key issues in a series of analytical procedures. On-line sample pretreatment with an automated chromatographic system is often used for effective and reliable extraction and analysis. On-line solid phase extraction (SPE) has contributed to high-throughput LC-MS/MS analysis. Pretreatment is conducted with a SPE column in a few minutes and the extract is analyzed by UHPLC-MS/MS. Another pretreatment method, supercritical fluid extraction (SFE), has been a commonly used substantial extraction technique and applied for extraction of bioactive compounds, drugs, lipids, and contaminants from natural products. SFE with supercritical carbon dioxide (SC-CO2) has advantages such as low consumption of organic solvents and low toxicity. SC-CO2 is also readily removed after use. In this study, chloramphenicol (CAP) in honey was determined by on-line SPE-LC-MS/MS and the compound in milk powder was determined by on-line SFE-SFC-MS/MS.

Content Type:
Paper
Document Number:
PO-CON1617E
Product Type:
Liquid Chromatograph-Mass Spectrometry
Keywords:
honey Powdered milk On-line sample pretreatment UHPLC-MS/MS supercritical fluid extraction (SFE), Food and Beverages, Food safety (Residues, Contaminants), DMPK, ADME, Safety testing, LCMS-8050 SPE-LC-MS/MS
Language:
English
File Name:
hko116018.pdf
File Size:
159kb

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