Screening Analysis of Highly Polar Doping Agents in Urine Using 2DLC/MS/MS

The use of performance-enhancing drugs, or "doping," has been recognised for decades and since 1999 the World Anti-Doping Agency (WADA) has governed and harmonized the worldwide sports drug testing efforts. However, these needs are changing and the continuing. discovery of new doping strategies with naturally occurring substances, such as androgenic steroids, pro-hormones and related metabolites, peptide hormones, as well as the emergence of designer drugs and the manipulation of blood and blood components results in sports drug testing methods which are capable of a range of tests. In this application news, we report the simultaneous analysis of highly polar doping agents including meldonium and adrenergic agents such as synephrine, norfenefrine, etilefrine, oxilofrine and octopamine using 2D LC/MS/MS.