Non-convex quasi-norm-based normalization of MALDI-MS Imaging Data

Normalization is used as a pre-step before applying multivariate techniques or to improve visibility in MALDI imaging datasets. Total ion count (TIC) normalization calculates the normalization factor for each pixel as the l1-norm of the signal intensities. It has been found to be less prone to artefacts compared to variations based on higher norms (i.e., l2 or RMS, l∞ or maxima-based). We investigate the use of generalized lp-quasi-norms, with 0 < p < 1. As p gets smaller, the increasing influence of smaller signal intensities in the normalization factor tend to be even less prone to artefacts, but normalization ranges become less uniform across pixels. A reasonable trade-off is proposed within 0.75 ? p ? 1.

Content Type:
Paper
Document Number:
PO-CON1559E
Product Type:
Mass Spectrometry, Life Science Lab Instruments, MALDI-TOF Mass Spectrometry
Keywords:
Non-convex quasi-norm-based, angiotensin peptide, Pharmaceutical, Life Science, MALDI-MS Imaging, MALDI-7090
Language:
English
File Name:
uko315071.pdf
File Size:
693kb

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