PHARMACEUTICAL
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Biopharmaceutical
Protein characterization, Impurity analysis for quality assurance
Shimadzu supports widely the analysis of biopharmaceuticals such as antibodies, cytokines, peptides and nucleic acids for manufacturing to meet the guidelines. For their characterization and impurity analysis, there should be a different attention and care in comparison with those of traditional chemical compounds. Our unique tools and unprecedented systems ensure the QA/QC of biopharmaceuticals with reproducible and reliable data in these new fields.
- Protein sequencer
- The PPSQ-31A/33A protein sequencer utilizes isocratic HPLC separation and Edman chemistry to deliver certain sequence information with very high confidence.
- MALDI-MS
- MALDI-MS systems provide reliable mass information with higher sensitivity and throughput for molecular identification and characterization.
The AXIMA Resonance shows excellent performance without compromise for both resolution and accuracy in structural studies, including protein modification analysis.
- LCMS-IT-TOF
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The LCMS-IT-TOF MS is a novel hybrid mass spectrometer for biomolecular analyses.
The combination of well-developed hardware and software application allows you to use a wide variety of analysis modes.
- Spectrophotometers
- The BioSpec-mini, dedicated compact spectrophotometer delivers quantitative measurements of proteins and nucleic acids.
- Liquid Chromatography
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On-line column switching LC system, Prominence Co-Sense enables higher efficiency analysis for the protein and peptides.
Prominence series provides excellent results in the specific application such as amino acid analysis.
- Nano-Flow Liquid Chromatography
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The Prominence nano supports higher precision protein and peptide analysis.
This system also serves as a front-end LC for LC/MS or off-line LC-MALDI system in combination with the powerful MALDI Spotter AccuSpot.The Reflux Flow Control System (patent pending) provides excellent reproducibility of nano-flows.
- Peptide synthesizer
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Multiple peptide synthesizer PSSM-8 can synthesize up to eight peptides simultaneously.
It is useful for antibody production, epitope mapping and the research of structure/activity relationship.
- TOC
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Total Organic Carbon measurement is a technique that determines the total amount of organic substances in water or solid samples.
TOC is the method of choice for biopharmaceutical cleaning validation.
- Balances
- Shimadzu offers a wide selection of balances to meet various user and lab environment needs.
