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Drug Discovery
Biomarker Discovery, Screening & Drug Synthesis
Shimadzu provides both analytical and medical instrument technologies for drug discovery research. The goal of drug discovery is to qualitatively investigate a large number of compounds, narrow the selection through more targeted synthesis and then screen, optimize and select the seed compounds to deliver potentially viable therapeutic candidates. Shimadzu is leveraging and fusing its core analytical and medical technologies to deliver powerful new drug discovery platforms. A specific focus is to develop advanced technologies in the area of molecular imaging.
Biomarker Discovery System
The LCMS-IT-TOF is a novel hybrid mass spectrometer for biomarker discovery, metabolite identification and human health research. The combination of well-developed hardware and software applications allow researchers to use a wide variety of analysis modes.
The AXIMA series provides linear, linear/reflectron and TOF/TOF MALDI mass spectrometers for drug discovery applications.
Ultra Fast MW Confirmation LC/MS System for Synthetic Compounds
Once a target compound is synthesized, it needs to be confirmed as quickly as possible for downstream processes. An Ultra Fast MW Confirmation system consisting of Prominence UFLC and an LCMS-2020 mass spectrometer is a powerful choice for such analysis. LCMS-2020 captures all the narrow peaks separated by Prominence UFLC in shorter run times. LCMSsolution software also supports easier operation and integrated workflows.
Preparative Isolation LC System with MS for Chemical Synthesis
High purity and high efficiency are important in preparative isolation process, particularly for such next steps as efficacy and pharmacokinetic studies. Shimadzu LC modular systems are flexible and allow configurations required for preparative scale chromatography. PsiPortTM software and the LCMS-2020 mass spectrometer ensure qualitative and quantitative analyses of target fractions. A 'one click' approach to sample analysis allows to use pre-configured methods and customized reporting templates.
In-vivo Molecular Imaging System for Small Animals
Clairvivo PET is used for in vivo molecular imaging of small experimental animals.In the field of oncology, PET imaging is used for tumor detection, disease staging and monitoring. Small animal PET imaging is also being used to study expression, drug uptake and brain function. combination of PET and MS provides a powerful discovery imaging platform.
