Drug Discovery

Biomarker Discovery, Screening & Drug Synthesis

Shimadzu provides both analytical and medical instrument technologies for drug discovery research. The goal of drug discovery is to qualitatively investigate a large number of compounds, narrow the selection through more targeted synthesis and then screen, optimize and select the seed compounds to deliver potentially viable therapeutic candidates. Shimadzu is leveraging and fusing its core analytical and medical technologies to deliver powerful new drug discovery platforms. A specific focus is to develop advanced technologies in the area of molecular imaging.

  • solution
  • systrm lineup

MALDI-MS
MALDI-MS
MALDI-MS systems provide reliable mass information with higher sensitivity and throughput for the molecular identification and characterization. In particular, the LCMS- IT-TOF MS system shows superior performance without compromise on high resolution and accurate structural analyses.Shimadzu is also exploring more advanced technology like MS imaging.

LC-AccuSpot-MALDI system
LC-AccuSpot-MALDI system
The AccuSpot is high capacity LC peak spotting system designed for off-line LC-MALDI analysis. It helps to increase sequence coverage for the detected proteins.

Chemical printer
Chemical printer
The CHIP-1000 chemical inkjet printer delivers picoliter volumes of solutions using piezoelectric technology. It is a unique platform for micro-scale life science related research.

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LCMS-IT-TOF
LCMS-IT-TOF
The LCMS-IT-TOF is a novel hybrid mass spectrometer for biomarker discovery, metabolite identification and human health research. The combination of well-developed hardware and software application allows you to use a wide variety of analysis modes.

LC-MS single quadrupole
LC/MS
The LCMS-2020 is newly launched single quadrupole mass spectrometer. When used in combination with Prominence UFLCXR, this system delivers easy-to-use compound confirmation.

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Liquid chromatography
Liquid chromatography
Modular types of LC, Prominence series and integrated types of LC, LC-2010 series cover the wide range of application. Prominence UFLCXR system accelerates the research process with its capability of higher pressure limit, reproducibility and robustness.

Prep-scale liquid chromatography
Prep-scale liquid chromatography
Shimadzu LC systems for purification are widely used in the synthesis lab. The combination with LCMS-2020, the purification process are accelerated and the purified substances’ quality is improved. UV signal triggered preparation LC systems are also able to be configured depends on the purification scale. Mass directed purification support. PsiPortTM mass directed auto-purification software has been designed to help accelerate compound isolation and auto-purification by preparative LC/MS.

nano-scale liquid chromatography
nano-scale liquid chromatography
The Prominence nano supports higher precision analysis of the proteins and peptides as front-end LC for LC/MS. Reflux Flow Control System (patent pending) provides excellent reproducibility of nano-flow.

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Microchip electrophoresis system
Microchip electrophoresis system
The MCE-202 MultiNA microchip electrophoresis system quickly and easily performs DNA and RNA nucleic acid size confirmation and quantitation.

Spectrophotometer
Spectrophotometer
The BioSpec-mini is a dedicated compact spectrophotometer that delivers quantitative measurements of DNA, RNA and proteins.

Balances
Balances
Shimadzu offers a wide selection of balances to meet various user and lab environment needs.

Laboratory Animal PET Imaging
PET System for Small Animals
The Clairvivo PET is used for in vivo molecular imaging using the small experimental animals. The combination of PET and MS imaging becomes powerful tool in the drug discovery area.

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