Clairvivo PET System for Small Laboratory Animals

As the only manufacturer of clinical PET systems in Japan, Shimadzu has been involved in research and development for over a quarter century. Our technology has led to the development of the Clairvivo PET, a PET (positron emission tomography) system for use with small laboratory animals.

The Clairvivo PET enables high sensitivity measurements of changes that occur to a particular small animal over time. Its advantages will be appreciated in basic research investigating vital phenomena at the molecular level, and in the field of drug development research, evaluating drug kinetics and efficacy.

The name "Clairvivo" is derived from
Clairvoyance
(second sight, profound insight, and internal visualization)
+
In vivo (Observation of live specimens)

Clairvivo PET System for Small Laboratory Animals

Features

Achieves both high sensitivity and high resolution

  • High sensitivity is achieved by adopting LYSO as the detector scintillator*1.
  • Both high sensitivity and high resolution have been achieved by adopting a cutting-edge DOI detector*2.
  • A cross sectional internal FOV of 100 mm is ensured, which is compatible with measurements of rats and marmoset's.
  • An axial FOV of 150 mm has been achieved, which is compatible with dynamic measurements of mice and rats, without position changes.

Achieves high level quantitative analysis and quick measurements

  • The transmission measurement *3 time has been reduced by using a 137Cs source.
  • 137 Cs has a half life of approximately 30 years, which means substantial reductions in maintenance costs.
  • The transmission radiation source can be stored within a shield, enabling emission measurements *4 to be performed with the radiation source left installed.
  • A special transmission space is ensured in order to prevent contact between the laboratory animals and the radiation source.

In pursuit of excellent operability

  • A seamless flat table has been adopted, with consideration to user friendliness for the experimenter. There is also room for peripheral instruments for anesthetic etc.
  • Laboratory animals are monitored with a camera featuring excellent visibility.
  • The animal bed is easily removed and attached.
  • The image processing console provides a wealth of applications based on know how cultivated over many years of experience with clinical PET systems.
*1 Scintillator: This element converts gamma rays into an optical signal. LYSO offers significant light generation with short light attenuation times, enabling high sensitivity measurements.
*2 DOI detector: This is an abbreviation for Depth-of-Interaction, a 3-dimensional radiation detector. This enables high resolution measurements with no degradation in resolution.
*3 Transmission measurement: Gamma rays are measured from an external radiation source, providing data for calibrating gamma ray absorption.
*4 Emission measurement: Gamma rays are measured from a radioactive tracer within the body of the animal.

* The appearance and specifications are subject to changes due to improvements without notice.
* This product is currently available only in Japan.

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