Life Science Research for Pharmaceutical

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Genomics, Proteomics, Metabolomics, Glycomics

Shimadzu offers a total solution to researchers working within pharmaceutical industries. Our integrated workflows give them accurate and comprehensive data, resulting in the efficient discovery of targets and biomarkers, and rapid selection and validation of drug candidates. We provide unique tools novel systems for the analysis of nucleic acids, proteins, peptides and saccharides.

Genomics Research

From direct DNA amplification using a drop of blood (Ampdirect plus) to automated DNA/RNA fragment analysis (MultiNA), our reagents and instruments offer a comprehensive solution to genomics research.

Proteomics Research

Disease and/or phenotype specific proteins are important targets in basic pharmaceutical research. Gel-separated proteins or chromatographically resolved peptides can be characterized and identified by high throughput MALDI TOF Mass Spectrometry using the Shimadzu AXIMA series.
These MALDI mass spectrometers can also serve as robust detection systems using off-line LC-MALDI. Stable isotope labeling (with ¹³CNBS reagent), nanoLC (Prominence nano) and the LC-MALDI coupling (AccuSpot) enable comparative proteome analyses and biomarker discovery experiments.

Glycomics Research

Glycosylation is a key post-translational modification associated with the function of many proteins. By using the unique hybrid MALDI-TOF MS AXIMA-QIT, detailed structure of the glycan and the site of post translational modification can be determined.

Metabolomics Research

The combination of accurate and sensitive MSn analysis with the LCMS-IT-TOF mass spectrometer and the Profiling Solution statistical analysis tool make it possible to mine metabolic markers from highly complex biological samples.

MALDI-MS Imaging

MALDI-MS Imaging allows researchers to analyze the spatial distribution of target molecules in tissue samples. Proteins, lipids and even drugs and their metabolites can be analyzed directly from tissues.
The combination of chemical inkjet printing (CHIP-1000) and high sensitivity MSn analysis (AXIMA-QIT) allow protein, peptide and drug distributions to be determined from classical histological tissue samples. Also, a unique hybrid MALDI-MS microscope is under development, enabling researchers to combine optical microscopy with sensitive and accurate MALDI-MS.

Laboratory Animal PET Imaging

Clairvivo PET is used for in vivo molecular imaging.
disease staging and monitoring. Small animal PET imaging is also being used to study gene expression, drug uptake and brain function.

Direct Imaging of Biomolecules

The scanning probe microscope SPM-9600 allows biomolecules such as DNA and proteins to be directly observed without any sample coating or pretreatment. For example, it can be applied to DNA/protein interaction imaging.

Nanoparticle Size Analysis

The SALD-7101 nanoparticle size analyzer was developed for the rapid measurement and observation of particles in the 10nm to 300 µm range. Therefore, SALD-7101 can observe the process of protein aggregation (ex. antigen/antibody reaction, protein-protein interaction) without the need for sample labeling.

PHARMACEUTICAL