Workstation Software for Gas Chromatograph-Mass Spectrometry
Extensive support for creating MRM methods
Smart MRM makes method development quick and easy.
Whether starting from scratch to optimize transitions and collision energies for new compounds, or starting from an MRM database of known target analytes to build a custom MRM method,
Smart MRM takes the stress an difficulty out of method development.
Compounds and Optimized Transitions -Smart Database-
The Shimadzu "Smart Database" is a database file for creating the method files using "Smart MRM" function. In addition to compound information and transitions, retention index can be registered in the database file. Method creation can be proceeded without calculating the retention time by analyzing the standard samples when using the Automatic Adjustment Retention Time (AART) function. In addition to MRM Smar t Database information, Scan and SIM ion information, mass spectra and calibration curve information from the internal standard method can also be registered in the database file. This allows users to create their own database easily.
The Smart MRM technology automatically creates methods with measurement times optimized for each component based on the Smart database. The Automatic Adjustment of Retention Time (AART) function incorporated in the system estimates retention times with high accuracy. When creating methods for simultaneous multicomponent analysis, the complicated process of configuring measurement parameters made it difficult to prepare appropriate methods. By using the Smart MRM function, however, it is possible to automatically create methods in which data are acquired with high sensitivity only during the elution time of the target components. In addition to MRM methods, SIM methods can be created.
Determining and optimizing MRM transitions for new compounds can require significant development time.
The "MRM Optimization Tool" automates the process by collecting product ion scan data and finding the optimum collision energy for each transition. Once established, the transitions are registered to one of the Shimadzu “Smart Database” files, and the MRM or Scan/MRM methods are created using Smart MRM.