Hydrophilic interaction chromatography (HILIC) is an increasingly popular separation mode that can be used to improve the retention of challenging polar analytes.
Shim-pack Velox HILIC using unbonded core shell particles is specifically designed for this application.
- Orthogonal selectivity to reversed phase chromatography
- Increased retention of polar analytes
- Increased MS sensitivity
- Direct compatibility with sample preparation eluates
Retention of Nucleosides
Nucleosides are polar molecules that are not well retained on reversed phase LC columns due to their hydrophilic nature are well retained and separated with Shim-pack Velox HILIC column.