The scalability of columns used in method scouting is important for method development. Shim-pack GIS/GIST/GISS series columns are available in sizes from 5 mm, suitable for HPLC analysis, to 2 mm, suitable for UHPLC analysis, allowing smooth transfer of analytical methods obtained by UHPLC method scouting for HPLC analysis. The series is also available with a wide range of modified groups, which are powerful tools in method development.
Shim-pack GIS Series
Genuine Ideal Symphony Ideal Generic HPLC Columns
Shim-pack GIST Series
Genuine Ideal Symphony Tenacity Highly Stable, Highly Durable
Shim-pack GIST series columns are packed with high-purity porous spherical silica. Their increased inertness not only improves peak shapes, but also increases durability. The series columns also have a large working pH range (1 to 10), and are designed for ease-of-use during analysis of a wide variety of compounds.
Reproducibility between production lots is also excellent, with the series columns recommended not only for quality control and research and development, but also for people just starting out in analysis.
This series is available in a variety of pore sizes, which makes it easy to migrate methods between conventional and ultra-high-speed analysis.
Shim-pack GISS Series
Genuine Ideal Symphony Speed Robust Inertness, High-Speed Analysis
Enables Both HPLC and UHPLC Analysis
The Nexera-i MT is a new addition to the i-Series Plus lineup. It enables both conventional analysis via its high compatibility with existing LC systems and rapid analysis via high-speed methods. In pharmaceutical development, a single integrated system allows process synthesis screening analysis for synthetic substances in the UHPLC flow line, and impurity content identification in the HPLC flow line.
Analysis results from LC systems in the same laboratory may differ, even with the same method, due to differences in the volumes of these systems. The Nexera-i MT demonstrates outstanding reproducibility between various LC systems with different system volumes, simplifying method transfer between instruments.
Further more, with the Nexera-i MT the process of migrating from UHPLC to HPLC or from HPLC to UHPLC can be accomplished using a single system.
The Nexera-i MT is based on the same user-friendly i-Series Plus, but maximizes performance and reliability for migrating and transferring customer methods.
A single integrated system allows analyses in two flow lines with UHPLC and HPLC delay volumes. In addition to simplifying the transfer of analytical methods for customers using HPLC, it can also streamline the process of converting customers' analytical methods from HPLC to higher-speed UHPLC.
▶Supports Method Compatibility Compliant with the United States Pharmacopeia
General Chapter <621> Chromatography in the United States Pharmacopeia specifies allowable ranges for changes to analytical parameters, so that revalidation is not necessary as long as the setting values remain within those allowable ranges. Nexera-i MT includes dual flow lines for HPLC and UHPLC analysis. With two system volumes, it can support both existing analytical methods and UHPLC methods.
The newly developed Analytical Condition Transfer and Optimization (ACTO) function incorporated in LabSolutions allows users to transfer injection timings matched to differences in system volumes between instruments, without editing the concentration gradient programs in existing methods.
▶More Optimal Method Transfer with a Simple Operation
Reproducing analysis results is difficult even when the same columns and the same mobile phase conditions are used, because the gradient analysis start times differ due to differences in internal volumes between LC systems. With the ACTO function, differences in internal volume can be fine-tuned to heighten data reproducibility between different systems and streamline method transfer.
Achieves Seamless Method Transfer Process
▶Transfer Methods with a Single Button Operation—ACTO Function
The ACTO function also includes functionality for transferring HPLC methods to UHPLC methods. Just by loading method files prepared on an existing system and entering information about the columns used, the optimized methods will be presented for fast analysis. By selecting one of the flow lines, the function can also transfer methods from UHPLC to HPLC.
The Nexera-i MT has two flow lines matched to the UHPLC and HPLC delay volumes. In addition to simplifying method transfer for customers using HPLC, this single integrated system also streamlines reviewing procedures for increasing the speed of customers' methods using UHPLC.
Designed for User-Friendly Operability
i-Series Plus is now compatible with method scouting systems.* Attaching a flow line switching valve allows up to six columns and four mobile phases to be switched automatically for analysis and to obtain optimum conditions for separation. Many i-Series Plus systems are used in manufacturing departments and other areas due to their simplicity, and performing method development with the same system improves the efficiency of method migration operations.
* Not including Nexera-i MT