Nexera MX

Simple Workflow Supports High Throughput

When multiple drugs are taken at the same time, there is a risk that CYP inhibition will result in side effects or attenuation of medicinal efficacy. Accordingly, it is necessary to understand the CYP molecule species inhibited by the compounds. This section introduces the sequence of procedures for performing MRM optimization in advance for target compounds known to be substrates of CYP molecule species, creating an analysis method from the MRM transition information registered in the database, and performing real-time batch and data analysis. 

LabSolutions Connect

1 Extract MRM transitions

  • Open a compound database file.
  • Select a compound list of drugs for analysis.

2 Create method and batch files

  • Select the LC method used for analysis.
  • Enter the settings required for real-time batch (vial positions, settings for calibration curves, etc.).
     

3 Execute analysis and manage batch queue

  • Start realtime batch.

 LabSolutions Insight

Data Analysis and Report Creation

  • Check the concentration values for substrates while displaying in parallel the substrates for analysis and the configured IS peaks.

Even when multiple drugs are grouped for cassette administration, it is easy to extract only the required MRM transition information from the registered database, and then create an analysis method. LabSolutions Connect is a very powerful tool for automating and heightening the efficiency of the entire sequence, from creating method files to performing analysis, and even analyzing data. 

Data Analysis and Report Creation

  • Check the concentration values for substrates while displaying in parallel the substrates for analysis and the configured IS peaks.

Even when multiple drugs are grouped for cassette administration, it is easy to extract only the required MRM transition information from the registered database, and then create an analysis method. LabSolutions Connect is a very powerful tool for automating and heightening the efficiency of the entire sequence, from creating method files to performing analysis, and even analyzing data. 

LabSolutions Connect was developed to make full use of the high-throughput performance of Nexera MX. It seamlessly supports the series of operations from MRM optimization to batch queue execution, improving process efficiency.

 Processing Large Amounts of Data by LabSolutions Insight

Large-volume data sets obtained after data acquisition are analyzed using LabSolutions Insight. With LabSolutions Insight, the MRM chromatograms to be reviewed  can be displayed in a stack. In addition, peak identification can be collectively processed via manual operation for peaks displayed. This reduces the time required for data processing, enabling more efficient data review.

For Research Use Only. Not for use in diagnostic procedures.

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