Preparative system general HPLC: Nexera Prep

Excellent System Expandability

Solvent Delivery Unit Accommodates a Wide Range of Recovery Volumes

Guidelines for Preparative Scale and Maximum Load

Guidelines for Preparative Scale and Maximum Load

The figure at right shows the guidelines for total component capacity with a 250 mm long column when the target component is highly soluble in the mobile phase, separates from impurities, and ions are suppressed. For isocratic elution, in principle, the total component capacity is proportional to the column volume.

Guidelines for Preparative Scale and Maximum Load


  • This solvent delivery unit can handle flow rates ranging from those used in analytical scale to those used in semi-preparative (up to 10 mL/min).
  • High-precision analysis is possible even in the semi-micro flow-rate range.

Supports Semi-Preparative and Recycle Preparative


  • This solvent delivery unit can handle flow rates used in semi-preparative scale (up to 20 mL/min).
  • Using a recycle kit enables semi-preparative recycling.

Supports Large-Scale Preparative Fractionation


  • High flow rates (up to 150 mL/min) enable highly efficient, large-scale preparative fractionation.
  • Large-scale prep solvent delivery fully supports the preparative fractionation workflow including reinjection to assess purity.
  • Combine with an FCV-200AL low-pressure gradient unit to perform gradient analysis using up to four mobile phases.
  LC-20AT LC-20AR LC-20AP
Solvent delivery method Series-type double plunger Parallel-type double plunger
Plunger capacity Primary side: 47 μL, Secondary side: 23 μL 47 μL 250 μL
Maximum discharge pressure 40 MPa 49 MPa 42 MPa
Flow rate setting range 0.001 to 10.000 mL/min 0.001 to 20.000 mL/min 0.01 to 150.00 mL/min
Flow rate accuracy
No more than ±2% or ±2 μL/min,
whichever is greater (0.01 to 5 mL/min)
No more than ±1% or ±10 μL/min,
whichever is greater (0.1 to 5.0 mL/min)
No more than ±1% (1 mL/min, 10 MPa)
Flow rate precision No more than 0.06% RSD or 0.02 min SD,
whichever is greate
No more than 0.08% RSD or 0.02 min SD, whichever is greater No more than 0.1% RSD or 0.02 min SD,
whichever is greater
Constant pressure solvent delivery Supported
Plunger rinsing mechanism Syringe or rinsing pump Syringe or rinsing pump
Operating temperature range 4 to 35 °C 4 to 35 °C 4 to 35 °C
Size and weight W 260 x H140 x D 420 mm,11 kg W 260 x H140 x D 500 mm,16 kg W 260 x H210 x D 500 mm,19 kg

Shim-pack Scepter Columns

- Excellent stability & performance using a wide range of LC conditions -

Shim-pack Scepter LC columns, which are the next generation organic silica hybrid based columns, are designed for stability and performance in a wide range of mobile phase conditions. With different chemistry characteristics, Shim-pack Scepter columns are effective for method development/scouting under conditions that may compromise traditional silica based columns.
With different particle sizes (1.9 μm, 3 μm, 5 μm) and different column dimensions, Shim-pack Scepter LC columns are fully scalable between UHPLC, HPLC and preparative LC, making method transfer seamless between different laboratory instrumentation.

Shim-pack Scepter Reversed Phase
C18 HD-C18 C8 Phenyl PFPP
Functional Group Trifunctional C18 Trifunctional C18 Trifunctional C8 Trifunctional
Generic Purpose Type High Density Type
Particle Organic Silica Hybrid
Particle Size 1.9 μm,3 μm,5 μm
Pore Size 12 nm 8 nm 12 nm
End Capping Proprietary None
pH Range 1 - 12 1 - 10 1 - 8
100% Aqueous Condition Yes No No Yes Yes
USP Classification L1 L1 L7 L11 L43

For Research Use Only. Not for use in diagnostic procedures.

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