Development > Characterization Analysis
Precise Glycan Structural Analysis
As the glycans in glycoproteins such as antibody drugs are added by the actions of multiple enzymes after protein translation, the diversity and non-uniformity of the glycan structure is an unavoidable problem. Guidelines require analysis of the glycan structures to the maximum possible extent. Due to reports indicating the relationship between the existence of fucose (one component of glycans) and antibody-dependent cellular cytotoxicity (ADCC), for example, glycans in antibody drugs will become increasingly important for research and development in the future.
MSn Spectra Analysis Has Enabled High-Accuracy Identification of Glycans
AXIMA Resonance employs unique Quadrupole Ion Trap technology for highly sensitive and accurate MSn spectral measurements of the molecular ions produced by MALDI.