LCMS-9030

Quadrupole Time-of-Flight Liquid Chromatograph Mass Spectrometer

Ionization Units

In addition to the standard ESI ionization unit, optional APCI and Dual Ion Source (DUIS) probes are available for the LCMS-9030 to meet various analytical needs. Shimadzu's DUIS offers an efficient combination of ESI and APCI ionization capabilities.

  Calibrant Delivery System (CDS)

The CDS allows calibration standards to be introduced via a separate ionization probe that functions independently from the main probe. This optional sub-ionization unit is installed in the main probe housing and is available for all probe types (ESI/APCI/DUIS). By having two probes in one system, high-concentration calibration standards can be introduced only when needed without switching flow lines, and are kept in isolation from the sample stream, eliminating contamination.

  Micro-ESI 9030 Micro-flow Ionization Unit

Shimadzu’s Nexera Mikros microflow system combines the sensitivity improvements you expect from a low-flow system with the ruggedness of HPLC. Designed for optimal sensitivity and ease of use, the Micro-ESI 9030 interface brings microflow analysis to the Q-TOF. Ionization efficiency and transfer have been maximized by the probe design, resulting in high sensitivity, stable operation, and minimal contamination. To minimize dead volume and diffusion, the Nexera Mikros features an innovative snap-in column locking system, the UF-Link™, allowing any user to correctly install a microflow column without disrupting the ESI spray needle position. Realize the benefits of microflow while enjoying the reliability of HPLC.

 

 

Nexera Mikros & Micro-ESI 9030 System


View from the Top of the Instrument

LabSolutions Insight™ Explore

  Software for Both Qualitative and Quantitative Analysis

LabSolutions Insight Explore offers an intuitive and full-featured quantitative environment with significant qualitative enhancements. A sophisticated peak detection algorithm detects chromatographic features based on their accurate mass. Resulting peak displays enable ranked formula prediction with theoretical spectral matching. A deconvolution algorithm is also provided for analysis of polyvalent ions.

 

  Quantitative Analysis

High-sensitivity MRM (Multiple Reaction Monitoring) analysis performed on the LCMS-9030 can eliminate background interferences by using accurate mass detection. Used together with Shimadzu’s ion accumulation feature, extraordinary Q-TOF sensitivity is delivered. Insight provides a complete and flexible quantitative interface with user-defined flags to facilitate review by exception.

 

  Formula Prediction

To facilitate unknown identification, Insight integrates formula prediction capabilities. High-resolution accurate mass data is utilized to create a list of possible formulas, displayed according to user preference. Theoretical spectra and isotope patterns can be used for putative identification. In the example below, the pesticide Boscalid was identified in a green tea extract.

 
 
 
 

  Multivalent Ion Analysis (Deconvolution)

For the deconvolution of multiple charge state envelopes produced by large molecules, such as proteins and oligonucleotides, LabSolutions Insight Explore includes ReSpect. This multivalent ion analysis algorithm from Positive Probability Ltd detects related multi-charged peaks and calculates the mass of the original species. Excellent mass accuracy was obtained in the example below.

 

LCMS, UF-Qarray, UF-Lens, UFsweeper, UFaccumulation, UFgrating, UF-FlightTube, iRefTOF, DUIS, UF-Link and LabSolutions Insight are trademarks of Shimadzu Corporation.

Preprocessing

Software

For Research Use Only. Not for use in diagnostic procedures.

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