Liquid Chromatograph Mass Spectrometer
Compressed Ion Introduction (CII™)
The ion optical system used in the LCMS-IT-TOF leads to a novel ion introduction method referred to as Compressed Ion Introduction or CII, where the combination of the skimmer, octopole and first lens converts the continuous stream of ions into pulses for introduction into the ion trap. This method makes it possible to control the accumulation of ions before they are introduced into the ion trap, allowing the RF to be applied to the ring electrode at the instant that all of the CII-accumulated ions enter the ion trap. This new method of controlling the ion trap, which is quite different from a traditional ion trap, is adopted for the LCMS-IT-TOF. The development of this CII effectively couples the LC system to the MS and enables a dramatic improvement over the previously deficient ion capture rate of the ion trap, thereby increasing sensitivity.