Automated Scale-up from Analytical to Preparative LC/MS to accelerate compound Purification and isolation

LC/MS Purification Solutions

A unique solution to automate and optimize compound purification and isolation

Compound isolation, purity analysis, and impurity analysis in pharmaceutical drug development presents increasing challenges to the industry as there is a clear need to enhance productivity and ensure compliance with evolving regulatory requirements. Such challenges are common to the development of new chemical entities, generic pharmaceutical manufacturing and contract research organizations. To help enhance productivity in compound purification and isolation Shimadzu has developed ASAPrep (Automated Scale-up from Analytical to Preparative), a unique solution to automate and optimize the purification process.

Open Solution Purification

Shimadzu Open Solution Purification software has been co-developed with pharmaceutical scientists to enable an automated approach to walk-up sample submission and optimized analytical to preparative scale up for compound purification and isolation. Using embedded data processing parameters, the software automatically checks the spectral integrity of the target compound for possible co-elution and also looks for closely eluting peaks. If the target compound is sufficiently resolved from other compounds in the sample it is submitted for a focused gradient preparative LC purification to optimize purity and recovery. Samples with co-elution or partial separation close to the retention space of the target compound are highlighted for data review and are not automatically submitted for purification.

For Research Use Only. Not for use in diagnostic procedures.

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