Imaging Mass Microscope
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Overlaying MS images and optical microscope morphological images reveals the difference between the amounts of specific molecules in each minute organ and can relate molecular distribution to the biological functions of an organelle and morphological changes.
The above figures show the resultant images generated by overlaying MS images at different m/z (blue and yellow) and optical microscope morphological images. These figures clearly indicate that analysis of the localization of specific molecules combined with morphological images is a useful approach for investigating drug efficiency and toxicity in drug discovery.