Direct Determination of Pb in Whole Blood by Graphite Furnace Atomic Absorption Spectrophotometry (GF-AAS)

Lead (Pb) is a widely used, cumulative heavy metal which affects numerous body systems, including neurological, hematological, gastrointestinal, cardiovascular and renal. At present, ten (10) μg/dL (micrograms /deciliter) or 100 ppb (parts per billion) was adopted by the Centre for Disease Control & Prevention (CDC) in 1991 as an advisory level for environmental and educational intervention. Detection of Pb in blood can be performed using several methods including atomic absorption spectrophotometry (AAS), anodic stripping voltammetry (ASV) and inductively coupled plasma mass spectrometry (ICP-MS). The method of choice will rely on various aspects including analytical capability (i.e. LOD, LOQ), costs, and technical requirements (i.e. sample preparation). This application news will report on the analysis of Pb in whole blood using the Shimadzu AA-7000G (Graphite Furnace Atomizer) and the Platform-type Graphite Tube. The method presented is a quick way to determine Pb in whole blood as the sample was mixed with a matrix modifier solution prior to GF-AAS analysis.

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Elemental Analysis, Atomic Absorption Spectroscopy
GFA, AAS, Blood, Lead, Clinical research, Forensics, AA-7000G
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