Evaluation of Amyloid-β Aggregation by Fourier Transform Infrared Spectrophotometer (FTIR)
With FTIR, it is possible to evaluate the aggregation of amyloid-β by analyzing the amide I band around 1,650 cm-1, which originates from stretching vibration of the C=O group of the peptide bond. Because the 9 reflection ATR method introduced in this article makes it possible to evaluate amyloid-β aggregation by a simple operation with only a small amount of sample material, use of this technique in research and development is expected.
- Content Type:
- Application
- Document Number:
- A619
- Product Type:
- Molecular Spectroscopy, FTIR Spectroscopy
- Keywords:
- amyloid-β, amyloid fibrils, aggregation, secondary structures, spectroscopy, ATR method, Pharmaceutical, Life Science, IRTracer-100
- Language:
- English
- File Name:
- jpa220014.pdf
- File Size:
- 231kb