Several chemicals in fragrance products like perfumes or shower gels can cause allergic reaction. These compounds are defined as potential allergens and 24 chemicals plus 2 isomers were regulated by the EU. Cosmetic products are subdivided into leave on (e.g. perfumes, cremes) or rinse off (shower gels, soaps etc.). The analytical method was using GCMS with two columns of different polarity to avoid coelutions. The most efficient setup has been to use two columns connected to two different split/splitless injectors mounted straight into the interface of one mass spectrometric detector.
The scientific committee on consumer safety proposed to extend that list (SCCS/1459/11). Here we report about 59 chemical substances using a twin-line (weakly polar and WAX) GCMSMS method in order to achieve maximum selectivity applying optimized multiple reaction monitoring (MRM).