Quantitative Analysis of Stable Isotopes of Glucose in Blood Plasma Using Quadrupole GC-MS

In order to investigate the dynamics of glucose in living organisms, a stable isotope of glucose is administered, and its concentration in blood and tissues is measured with quadrupole GC-MS. In this study, we conducted a comparative investigation of the influence of the derivatization method on the results obtained in the quantitative analysis of D-glucose-13C6 using quadrupole GC-MS. As a result, it was discovered that aldonitrile-pentaacetylation gives a single derivatization product, and in mass separation performed with MS, it yielded good quantitative results with little influence by the natural isotopes of glucose that are present at high concentrations in living organisms.

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Gas Chromatograph-Mass Spectrometry, Mass Spectrometry
GC/MS, Glucose, Isotropic labeling, Plasma, Derivatization, Aldonitrile pentaacetate, Clinical research, Forensics, Hydrocarbon Processing Industry (Petrochemical, Chemical), Pharmaceutical, Life Science, Drug discovery, DMPK, ADME, Safety testing, GCMS-QP2010 Plus
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