Analysis of Potential Genotoxic Impurities in Active Pharmaceutical Ingredients (3) -Analysis of Haloalcohols and Glycidol Part 1-

Haloalcohols are used as synthetic materials in pharmaceuticals, and are considered potential genotoxic impurities (PGI). In addition, glycidol has been identified as a cancer-causing agent, and has been assigned to Group 2A (probably carcinogenic to humans) in terms of carcinogenic risk by the International Agency for Research on Cancer (IARC). This Application Data Sheet introduces analysis of haloalcohols and glycidol in an active pharmaceutical ingredient (API) using the GC-MS.

Content Type:
Application
Document Number:
LAAN-J-MS-E041
Product Type:
Mass Spectrometry, Gas Chromatograph-Mass Spectrometry
Keywords:
haloalchohols glycidol impurities pharmaceutical ingredients, Pharmaceutical, Life Science, DMPK, ADME, Safety testing, GCMS-QP2010 Ultra
Language:
English
File Name:
jpo212203.pdf
File Size:
128kb

View Article

PDF

Most of the documents on the LITERATURE is available in PDF format. You will need Adobe Acrobat Reader to open and read PDF documents. If you do not already have Acrobat Reader, you can download it free at the Adobe's Website. Click the GET ADOBE READER icon on the left to download a free copy of Adobe Acrobat Reader.

For Research Use Only. Not for use in diagnostic procedures.

This page may contain references to products that are not available in your country. Please contact us to check the availability of these products in your country.

Top of This Page