An Investigation of Simultaneous Analysis Methods for 420 Residual Pesticide Compounds in Foods Using GC-MS/MS

Due to its excellent sensitivity and selectivity, GC-MS/MS is utilized for the analysis of residual pesticides in foods. The number of relevant pesticides grows yearly, and has reached 300 to 400 compounds. Due to limitations in MRM-related software functionality and detection sensitivity, analyzing so many pesticides requires the intended pesticides to be divided into multiple method files and then measured method by method. As a result, the number of analyses increases, and places a strain on laboratory productivity. Smart MRM*, the method creation function in GCMSsolution software, automatically creates the optimal methods for the simultaneous analysis of over 400 compounds, while ensuring sensitivity and accuracy are maintained. In addition, MRM analysis can be started without configuring troublesome transition settings by utilizing Smart Pesticides Database, which contains acquisition parameters for 479 compounds. Since this database contains retention indices, retention times can be corrected with a single n-alkane analysis (AART function). Using the corrected retention times allows the user to start creating MRM methods without purchasing or analyzing an analytical standard.

This data sheet reports batch analysis methods for 420 compounds (approximately 1,200 transitions) using Smart Pesticides Database and Smart MRM.