Analysis of Glycan Structures Using Chemical Labeling and MALDI MSn Mass Spectrometry

Glycans play important roles in the function of glycoproteins in the human body. In this study, an AXIMA ResonanceTM was used to generate MALDI-IT-TOF MSn spectra for the analysis of glycan sequences without multistep separation or enzymatic treatment. Combining the carbohydrate oxidation reaction and MSn analysis allowed monitoring the oxidization reaction for sialylation and linkages of oligosaccharides.

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Content Type:
Journal
Document Number:
jpz18028
Product Type:
Keywords:
Shimadzu Journal, Vol.5, Issue1-October 2017, Clinical research, Forensics, Healthcare
Language:
English
File Name:
jpz18028.pdf
File Size:
281kb

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