Application of LC-MS/MS Analysis for Time-lapse Metabolomics in CHO Cell Culture
Metabolic analysis of Chinese hamster ovary (CHO) cell culture plays an important role for efficient production in the biopharmaceutical industry. In this study, amino acids concerned with these pathways were analyzed by LC-MS/MS (LCMS-8050, SHIMADZU) for time-lapse metabolic analysis of CHO-K1 cell batch culture. Results showed real-time changes of various metabolites during CHO culture, which may provide extensive and speedy investigational analysis for genomic and metabolic modifications in biopharmaceutical or medical progresses.
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- Content Type:
- Journal
- Document Number:
- jpz18031
- Product Type:
- Keywords:
- Shimadzu Journal, Vol.5, Issue1-October 2017, Clinical research, Forensics, Healthcare
- Language:
- English
- File Name:
- jpz18031.pdf
- File Size:
- 847kb