Fast GCMS determination of urinary organic acids for diagnosis of metabolism inborn errors

During normal metabolismactivities, the nutrientsobtained from food are metabolizedin the body, whichmeans that they are eitherstored or used as energy. Incase of inherited metabolicdisease, the patient lackscertain enzymes, which leadto an accumulation of unmetabolizedcompounds. Theseaccumulated compoundscause a severe toxicityacting on the nervoussystem, then they restrictand delay development andgrowth resulting in prematuredeath. For a quickscreening Liquid Chromatographywith Tandem MassSpectrometry is sometimesemployed, however, for aclose inspection and a highrisk screening of the organicacids, the best analyticaltechnique is Gas Chromatographycoupled to MassSpectrometry (GCMS).Here, we present a FastGCMS method that increasethe daily throughput ofanalysis.

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Content Type:
Application
Document Number:
SCA_280_067
Product Type:
Gas Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
Clinical research, Forensics, Healthcare, Clinical research, GCMS-QP2010
Language:
English
File Name:
appl_gcms_urine-organic-acids_07c_067_en.pdf
File Size:
86kb

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For Research Use Only. Not for use in diagnostic procedures.

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