Simultaneous determination of four immunosuppressants in whole blood - A fast method on a Shimadzu tandem LCMS-8030 mass analyser

The amount of different kind of organ transplantations is increasing steadily since the improvement of this technology in the past century. The European organization Eurotransplant counts several thousand surgical interventions in Europe every year. To avoid rejection of the transplanted organ by the immune system, a complex therapy of immunosuppressants in combination with other drugs is necessary. A therapeutic concentration range in blood minimizes the risk of unwanted side effects.Immunoassays which are an alternative method for monitoring immunosuppressants, often lead to insufficient results due to their cross reactivity to drug metabolites. In this study we established a fast, kit-based screening method for routine use of immunosuppressants based on LCMS/MS technology.

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Liquid Chromatography, Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
rejection of the transplanted organ, therapy of immunosuppressants, Clinical research, Forensics, Healthcare, Clinical research, Nexera, LCMS-8030
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