Toxicological screening for over 1000 compounds in an MRM based acquisition for Library ID in whole blood samples

A library of product ion spectra for 1222 compounds has been developed for clinical and forensic toxicology screening to help reduce false positive and false negative reporting. The library enables multi-targeted methods to be developed for routine screening, library identification and quantitation. The scope of the library considers two approaches; a MRM triggered full scan product ion spectra and MRM Spectrum mode. MRM Spectrum mode acquires a high number of fragment ion transitions for each target compound generating a fragmentation spectra which can be used in routine library searching and compound verification using reference library match scores. In this work, MRM Spectrum mode has been applied to analysis of patient samples to quantify and identify targets in whole blood samples extracted using a QuEChERS method.

*Not available in the U.S.

Content Type:
Paper
Document Number:
PO-CON1765E
Product Type:
Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
forensic toxicology, blood samples, Clinical and forensic library, Benzoylecgonine, Morphine, Benzoylecgonine, EDDP, Methadone, Ecgonine methylester,Hydromorphone, Clinical research, Forensics, Healthcare, Forensics, Toxicology, Drug test, LCMS-8060, Nexera UC
Language:
English
File Name:
ego117079.pdf
File Size:
261kb

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For Research Use Only. Not for use in diagnostic procedures.

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