Characterization of metabolites in microsomal metabolism of aconitine by high-performance liquid chromatography/quadrupole ion trap/time-of-fight mass spectrometry

Aconitine (AC) is a bioactive alkaloid from plants of the genus Aconitum, some of which have been widely used as medicinal herbs for thousands of years. AC is also well known for its high toxicity that induces severe arrhythmias leading to death. Although numerous studies have raised on its pharmacology and toxicity, data on the identification metabolites of AC in liver microsomes are limited.

The study of metabolic pathways is very important for efficacy of therapy and evaluation of toxicity for those with narrow therapy window. The aim of our work was to obtain the metabolic pathways of AC by the human liver microsomes.

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Mass Spectrometry, Liquid Chromatograph-Mass Spectrometry
Aconitine (AC), Aconitum, Bioactive alkaloid, Liver microsomes., Food and Beverages, Pharmaceutical, Life Science, Healthcare, Food safety (Residues, Contaminants), DMPK, ADME, Safety testing, LCMS-IT-TOF
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