Highly sensitive quantitative analysis of Amoxicillin and Clavulanic acid from plasma using LC/MS/MS
Amoxicillin and clavulanic acid is a combination drug product in which amoxicillin is a β-lactam antibiotic, and clavulanic acid is a β-lactamase inhibitor. In this combination, clavulanic acid acts by preventing the destruction of antibiotic amoxicillin which is used to treat various bacterial infections. LC/MS/MS has been increasingly employed in pharmacokinetic studies due to its specificity and sensitivity. This also allows the development of assays with minimal sample preparation.
- Content Type:
- Paper
- Document Number:
- PO-CON1546E
- Product Type:
- Mass Spectrometry, Liquid Chromatograph-Mass Spectrometry
- Keywords:
- Amoxicillin, clavulanic acid, β-lactamase inhibitor, Pharmaceutical, Life Science, Healthcare, Development (Formulation, Scale-up, Method development), Drug synthesis and purification, LCMS-8040
- Language:
- English
- File Name:
- ipo115064.pdf
- File Size:
- 116kb