Low level quantitation of Fluticasone and Salmeterol from plasma using LC/MS/MS

The combination drug of fluticasone/ salmeterol contains fluticasone propionate and salmeterol.
Fluticasone, a corticosteroid, is the anti-inflammatory component of the combination, while salmeterol treats constriction of the airways. Together, they relieve the symptoms of coughing, wheezing and shortness of breath related to asthma and Chronic Obstructive Pulmonary Disorder (COPD). LC/MS/MS has been increasingly employed in pharmacokinetic studies due to its specificity and sensitivity. This also allows the development of assays with minimal sample preparation.