Structural Analysis of Glycosphingolipids by LC-IT-TOF-MS

A method for detection and structural characterization of glycosphingolipids (GSLs) based on LC-IT-TOF-MS is introduced and the results of analysis of GSLs containing sialic acid in mouse thymocytes, CD4T and CDT8 cells are described as an example of its application. Even at trace levels and in a mixture, both carbohydrate chain and lipid structures were characterized, and previously unknown information could be obtained. The development of new analytical tool is in progress and applicable future challenges are discussed.

*Not available in the U.S.

Content Type:
Application
Document Number:
C146-E268
Product Type:
Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
glycosphingolipids, gangliosides, mouse T cells, microdomain, Clinical research, Forensics, Healthcare, Pharmaceutical, Life Science, DMPK, ADME, Safety testing, LC-IT-TOF-MS
Language:
English
File Name:
jpo114093.pdf
File Size:
828kb

View Article

PDF

Most of the documents on the LITERATURE is available in PDF format. You will need Adobe Acrobat Reader to open and read PDF documents. If you do not already have Acrobat Reader, you can download it free at the Adobe's Website. Click the GET ADOBE READER icon on the left to download a free copy of Adobe Acrobat Reader.

For Research Use Only. Not for use in diagnostic procedures.

This page may contain references to products that are not available in your country. Please contact us to check the availability of these products in your country.

Top of This Page

Please select your country or region.

Transferring to the local website of your country or region.

Transfer to
https://www.ssi.shimadzu.com/