High-Throughput Optimization of Therapeutic Drug Monitoring Using Fully Automated Sample Preparation LC/MS/MS System (CLAM-2000 + LCMS-8040)

TDM is used during drug treatment with drugs that pose administration management difficulties, such as drugs with a narrow therapeutic range or with an effective range and toxic range that are close to each other. High performance liquid chromatography (HPLC) has been the main analytical method used with TDM, but recently liquid chromatography-mass spectrometry (LC/MS/MS) is being used to improve analytical accuracy and precision based on its superior selectivity.This article introduces the results of TDM using a fully automated sample preparation LC/MS/MS system comprised of the CLAM-2000 fully automated LCMS sample preparation unit and the LCMS-8040 high performance liquid chromatograph-mass spectrometer.

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Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Therapeutic drug monitoring, TDM, Antiepileptic drug, Antiarrhythmic drug, Clinical research, Forensics, Healthcare, Pharmaceutical, Life Science, Toxicology, Drug test, LCMS-8040, CLAM-2000
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