High-Throughput Optimization of Therapeutic Drug Monitoring Using Fully Automated Sample Preparation LC/MS/MS System (CLAM-2000 + LCMS-8040)

TDM is used during drug treatment with drugs that pose administration management difficulties, such as drugs with a narrow therapeutic range or with an effective range and toxic range that are close to each other. High performance liquid chromatography (HPLC) has been the main analytical method used with TDM, but recently liquid chromatography-mass spectrometry (LC/MS/MS) is being used to improve analytical accuracy and precision based on its superior selectivity.This article introduces the results of TDM using a fully automated sample preparation LC/MS/MS system comprised of the CLAM-2000 fully automated LCMS sample preparation unit and the LCMS-8040 high performance liquid chromatograph-mass spectrometer.

*Not available in the U.S.

Content Type:
Application
Document Number:
LAAN-A-LM-E094
Product Type:
Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
Therapeutic drug monitoring, TDM, Antiepileptic drug, Antiarrhythmic drug, Clinical research, Forensics, Healthcare, Pharmaceutical, Life Science, Toxicology, Drug test, LCMS-8040, CLAM-2000
Language:
English
File Name:
jpo116010.pdf
File Size:
1,834kb

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For Research Use Only. Not for use in diagnostic procedures.

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