High-sensitivity, high-throughput quantitation of catecholamine metabolites in urine by LC/MS/MS for clinical research
Catecholamines and other neurotransmitters in circulation are readily metabolized to give vanillylmandelic acid (VMA), homovanillic acid (HVA) or 5-hydroxyindolacetic acid (5-HIAA), which are excreted to urine at much higher abundance than their precursor molecules. Given this and also the non-invasive nature of sample collection, urinary neurotransmitter metabolites are growing research target in clinical context. Our aim in this study is to accelerate clinical research by providing a fast and robust LC/MS/MS method for determining urinary neurotransmitter metabolites VMA, HVA and 5-HIAA.
*Not available in the U.S.
- Content Type:
- Paper
- Document Number:
- PO-CON1655E
- Product Type:
- Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
- Keywords:
- Clinical research, Forensics, Healthcare, Clinical research, LCMS-8060
- Language:
- English
- File Name:
- jpo116059.pdf
- File Size:
- 390kb