High-sensitivity, high-throughput quantitation of catecholamine metabolites in urine by LC/MS/MS for clinical research

Catecholamines and other neurotransmitters in circulation are readily metabolized to give vanillylmandelic acid (VMA), homovanillic acid (HVA) or 5-hydroxyindolacetic acid (5-HIAA), which are excreted to urine at much higher abundance than their precursor molecules. Given this and also the non-invasive nature of sample collection, urinary neurotransmitter metabolites are growing research target in clinical context. Our aim in this study is to accelerate clinical research by providing a fast and robust LC/MS/MS method for determining urinary neurotransmitter metabolites VMA, HVA and 5-HIAA.

*Not available in the U.S.

Content Type:
Paper
Document Number:
PO-CON1655E
Product Type:
Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
Clinical research, Forensics, Healthcare, Clinical research, LCMS-8060
Language:
English
File Name:
jpo116059.pdf
File Size:
390kb

View Article

For Research Use Only. Not for use in diagnostic procedures.

This page may contain references to products that are not available in your country. Please contact us to check the availability of these products in your country.

Top of This Page

Please select your country or region.

Transferring to the local website of your country or region.

Transfer to
https://www.ssi.shimadzu.com/