Simultaneous Analysis of Immunosuppressive and Antifungal Drugs in Human Blood Plasma Using LC/MS/MS
Mycophenolate mofetil, a prodrug for immunosuppressive drugs, is used to suppress rejection after organ transplantation. In addition, Voriconazole and Itraconazole are administered in combination as antifungal drugs to prevent infection after transplantation. This article introduces a simultaneous analysis of an immunosuppressive drug (mycophenolic acid), antifungal drugs (Voriconazole and Itraconazole) and metabolites using the LCMS™-8050 triple quadrupole high-performance liquid chromatograph mass spectrometer.
*Not available in the U.S.
- Content Type:
- Application
- Document Number:
- C196
- Product Type:
- Liquid Chromatograph-Mass Spectrometry, LC-MS/MS system
- Keywords:
- Therapeutic drug monitoring, TDM, Immunosuppressive drug, Immunosuppressant, Antifungal drug, Mycophenolate mofetil, Voriconazole, Itraconazole, Mycophenolic acid, Hydroxyitraconazole, Healthcare, DMPK, ADME, Safety testing, LCMS-8050
- Language:
- English
- File Name:
- jpo119124.pdf
- File Size:
- 79kb