Simultaneous Analysis of Immunosuppressive and Antifungal Drugs in Human Blood Plasma Using LC/MS/MS

Mycophenolate mofetil, a prodrug for immunosuppressive drugs, is used to suppress rejection after organ transplantation. In addition, Voriconazole and Itraconazole are administered in combination as antifungal drugs to prevent infection after transplantation. This article introduces a simultaneous analysis of an immunosuppressive drug (mycophenolic acid), antifungal drugs (Voriconazole and Itraconazole) and metabolites using the LCMS™-8050 triple quadrupole high-performance liquid chromatograph mass spectrometer.

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Content Type:
Application
Document Number:
C196
Product Type:
Liquid Chromatograph-Mass Spectrometry, LC-MS/MS system
Keywords:
Therapeutic drug monitoring, TDM, Immunosuppressive drug, Immunosuppressant, Antifungal drug, Mycophenolate mofetil, Voriconazole, Itraconazole, Mycophenolic acid, Hydroxyitraconazole, Healthcare, DMPK, ADME, Safety testing, LCMS-8050
Language:
English
File Name:
jpo119124.pdf
File Size:
79kb

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For Research Use Only. Not for use in diagnostic procedures.

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