High-sensitivity and simultaneous analysis of Psychoactive drugs using LC-MS/MS with full-automated pretreatment system
LC-MS/MS has become a preferred method for the routine analysis for forensic toxicology. LC-MS/MS allows for the simultaneous analysis of multiple compounds in a single run, thus enabling a fast and high throughput analysis. In recent years that it seems the number of incident and accident is increasing caused by dosed with psychotropic drugs and the number of drug testing with LC-MS/MS is also increasing to investigate the cause of death. However, manual sample preparation often involves several complicated manual steps which can introduce error into the results. In this study, we investigated the processing capability to analyze serum, whole blood and urine spiked sixty psychotropic drugs by LC-MS/MS with automated sample preparation unit.
*Not available in the U.S.
- Content Type:
- Paper
- Document Number:
- PO-CON1714E
- Product Type:
- Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
- Keywords:
- Psychoactive drugs, blood, urine, Amitriptyline, Amoxapine, Clomipramine, Desipramine, Dosulepin, Imipramine Lofepramine, Maprotiline, Mianserin, Nortriptyline, Promethazine, Setiptiline, Alprazolam, Bromazepam, Brotizolam, Chlordiazepoxide, Clorazepic, acid, Clotiazepam, Cloxazolam, Diazepam, Estazolam, Ethylloflazepate, Etizolam, Fludiazepam, Flunitrazepam, Flurazepam, Flutazolam, Flutoprazepam, Haloxazolam, Lorazepam, Lormetazepam, Medazepam, Mexazolam, Midazolam, Nimetazepam, Nitrazepam, Oxazolam, Prazepam, Quazepam, Rilmazafone, Tofisopam, Triazolam, Zolpidem, 7-Aminoflunitrazepam, 7-Aminonimetazepam, 7-Aminonitrazepam, α-Hydroxyetizolam, (M-VI), α-Hydroxyalprazolam, α-Hydroxybrotizolam, α-Hydroxytriazolam, Zolpidem, M-1, Clinical research, Forensics, Healthcare, Forensics, Toxicology, Drug test, CLAM-2000, LCMS-8060
- Language:
- English
- File Name:
- jpo17032.pdf
- File Size:
- 370kb
