Analytical method development for widely targeted perfluoroalkyl acids (PFAAs) and their precursors in plasma using multi-gradient eluent system by LC-MS/MS

As perfluoroalkyl acids (PFAAs) had been widely used because of their excellent surfactant. While the product and usage of perfluorooctane sulfonic acid (PFOS), its salts and perfluorooctane sulfonyl fluoride (PFOS-F) were restricted by the Stockholm Convention in 2009, many kinds of precursors which cause PFAAs by decomposition keep being used because they are not restricted.
LC-MS/MS analysis methods for PFAAs have been developed, where a high selectivity analysis is available, but it was very difficult to implement the simultaneous analysis of PFAAs and their precursors since the wideness of their chemical property in terms of hydrophilic / hydrophobic.
This time, we developed the analytical method for widely targeted PFAAs and their precursors in plasma using multi-gradient eluent system by LC-MS/MS.