The application of UHPLC and Ultrafast-LCMSMS to the analysis of small volume biological samples for drug residues

The analysis of specimens such as blood spots, hair and saliva for the presence of drug residues is limited by the sample size and the need to perform both screening and confirmatory analyses. Sample preparation techniques for such samples benefit from micro-scaled approaches that minimise the exposure of the sample to diluents and possible contaminants, poor recovery and the increased processing time associated with scale. These benefits are also highly desirable for high-throughput analysis of urine for measuring clinical and illicit drug residues and for metabolomic profiling where they simplify sample processing and for reducing transport and storage costs.
We couple Noviplex cards for the isolation of small molecules from hydrolysed urine, with UHPLC and Ultrafast-LCMSMS (UFMS) to detect low level drug residues and metabolites in small volume biological specimens with subsequent identification of unknowns using MS scan events.

*Not available in the U.S.

Content Type:
Paper
Document Number:
PO-CON1479E
Product Type:
Liquid Chromatography, Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
blood, hair, saliva, urine, Clinical research, Forensics, Healthcare, Pharmaceutical, Life Science, DMPK, ADME, Safety testing,Clinical research, LCMS-8050, Nexera LC-30
Language:
English
File Name:
opo114065.pdf
File Size:
665kb

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For Research Use Only. Not for use in diagnostic procedures.

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