Principles and practical applications of Shimadzu's ELSD-LTII evaporative light scattering detector
The principle of evaporative light scattering detectors (ELSD), which solve these problems, is extremely simple. The target components are converted to a fine spray by a nebulizer and heated so that only the mobile phase is evaporated. Light is directed at the remaining target substances and the scattered light is detected. ELSDs can detect almost all components that are less volatile than the mobile phase. These detectors first appeared in 1966, but were subsequently overshadowed by high-performance liquid chromatographs, which advanced significantly at that time.
- Content Type:
- Application
- Document Number:
- C190-E108
- Product Type:
- Liquid Chromatography
- Keywords:
- Pharmaceutical, Life Science, DMPK, ADME, Safety testing, Prominence
- Language:
- English
- File Name:
- c190e108.pdf
- File Size:
- 1,593kb