Investigation of Synthetic Compounds in Drug Discovery by Nexera-i and LCMS-2020

Operational efficiency is an important issue to researchers involved in the organic synthesis stage of drug discovery typically conducted at pharmaceutical companies and universities. Specifically, large numbers of drug candidates are synthesized daily in the drug discovery chemistry operations conducted throughout the pharmaceutical industry, and the synthesis and purity confirmation of these substances are primarily conducted by LC/MS. Typically, the LC/MS is treated as a shared instrument in an open-access environment, so rather than optimizing the analytical conditions for the various individual compounds, each type of compound is analyzed using a fixed set of analytical conditions. Reliable analysis in such an environment fundamentally requires an LC system that ensures low carryover performance.
Here, we introduce an example of analysis of eight pharmaceutical substances in a workflow that is typically used for pharmaceutical synthesis confirmation analysis.